HCID 10857231, compound → HCID 86609651, compound

HRID 2356272Notes

Reaction equation

HRID 2356272 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH3:16])/[CH:10]=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N[C@H](C)C(N(OC)C)=O)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][C@H:9]([CH3:16])/[CH:10]=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 10857231HCID 10857231, compoundHCID 23537239N~2~-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-D-alaninamide

Product 1

HCID 86609651HCID 86609651, compoundYield 79%

Procedure

The title compound was prepared as Methyl (2E)(4S)-4-[(tert-butoxy)carbonylamino]pent-2-enoate with (2R)-2-[(tert-butoxy)carbonylamino]-N-methoxy-N-methylpropanamide (13.05 grams, 56.18 mmol) to give the title compound (10.2 g, 79%): ES-MS (m/z) 230 [M+1]+.

Sources & evidence

ORD record
ord-58b284fdb3ce485794aad58264281fa0
Source dataset
uspto-grants-2010_07
Patent number
US07759342B2

Reaction notes

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