Acetyl chloride → HCID 178496609, compound

HRID 2356298Notes

Reaction equation

HRID 2356298 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][CH3:16])[CH2:11][CH2:10]1)=O)(C)(C)C.C(Cl)(=O)C>C(O)C>[CH3:16][O:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178496620HCID 178496620, compound

Product 1

HCID 178496609HCID 178496609, compoundYield 126.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

trans-(tert-Butoxy)-N-(4-methoxycyclohexyl)carboxamide (642 mg, 2.80 mmol) was dissolved in ethanol (5 mL) and cooled to 0° C. Acetyl chloride (1.5 mL) was added and the reaction was allowed to reach room temperature and stirred overnight. Solvent was removed in vacuo to give the desired product (458 mg, quantitative yield) as a hydrochloride salt. ES-MS: 130 (M+1).

Workup

  1. customto reach room temperature
  2. customSolvent was removed in vacuo

Sources & evidence

ORD record
ord-fc14cec8ed7e4ec682a782fa32b23529
Source dataset
uspto-grants-2010_07
Patent number
US07759342B2

Reaction notes

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