Dichloromethane → HCID 58899554, compound

HRID 2356376Notes

Reaction equation

HRID 2356376 reaction equation
[CH2:1]=[C:2]1[C:7](=[O:8])[CH:6]2[CH2:9][CH2:10][N:3]1[CH2:4][CH2:5]2.ClCCl>>[CH2:7]([O:8][CH2:1][CH:2]1[C:7](=[O:8])[CH:6]2[CH2:9][CH2:10][N:3]1[CH2:4][CH2:5]2)[CH2:6][CH3:5]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 3229732-Methylene-3-quinuclidone

Product 1

HCID 58899554HCID 58899554, compound

Procedure

To a stirred solution of 2-methylene-3-quinuclidinone (100 mg) in dry dichloromethane (5 ml) propanol (1 equiv., 0.04 ml) was added in presence of molecular sieves (4 Å). The reaction mixture was stirred at RT for overnight. The reaction mixture was filtered and the filtrate was concentrate to get crude product, which was purified (70 mg, 50%) by column chromatography on silica gel using 0.5% methanol in chloroform as eluent.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrate
  3. customto get crude product, which
  4. customwas purified (70 mg, 50%) by column chromatography on silica gel using 0.5% methanol in chloroform as eluent

Sources & evidence

ORD record
ord-e8b872e9c4724605a3c2a4823ada02f4
Source dataset
uspto-grants-2010_07
Patent number
US07759361B2

Reaction notes

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