反应详情

The preparation comprises dissolving [1S,6S]-8-benzyl-2-tertbutyloxycarbonyl-2,8-diazabicyclo[4,3,0]nonane (target product of Embodiment 5, 5.0 g, 15.8 mmol) in methanol (50 mL), adding 10% Pd/C (1.0 g) as catalyst for hydrogenation under 3 atm for 10 h, filtering to remove the catalyst, concentrating the filtrate, adding petroleum ether to solidify the product, filtering, and drying obtained filter cake to give [1S,6S]-2-tertbutyloxycarbonyl-2,8-diazabicyclo[4,3,0]nonane(3.1 g, 86.8%), [α]20D=−70.2° (C=4).

1. filtrationfiltering
2. customto remove the catalyst
3. concentrationconcentrating the filtrate
4. additionadding petroleum ether
5. filtrationfiltering
6. customdrying
7. customobtained
8. filtrationfilter cake