Azane;hydrate → HCID 67236507, compound

Participants

Reaction Steps

The preparation comprises neutralizing 5-amino-1-cyclopropyl-8-difluoromethoxyl-7-(cis-2,8-diazabicyclo[4,3,0]nonane-8-yl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid trifluoroacetate (target product of embodiment 19, 3.0 g) with ammonia water, refrigerating, filtering, and washing obtained solid with cold water to give monohydrate of the title compound. MS(m/z):453(M++1). Calculated results (measured values) of element analysis for the product: C 53.62(53.58), H 5.36(5.48), and N 11.91(11.87).

Provenance & Evidence