HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356391Generated: October 26, 2026
Potassium Carbonate → 4-(2-Ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-YL}-indol-1-YL)-benzoic acid ethyl ester
https://huagongshe.com/reaction/2356391
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Ethyl 4-iodobenzoate | HCID 142891 | — |
| Reactant | 2-Ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-yl}-1H-indole | HCID 57718837 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Catalyst | Zinc Oxide | HCID 3007857 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-YL}-indol-1-YL)-benzoic acid ethyl ester | HCID 11952525 | 26% |
Reaction Steps
To a mixture of 2-ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-yl}-1H-indole (430 mg), p-iodobenzoic acid ethyl ester (716 mg), potassium carbonate (359 mg), copper iodide (52 mg) and zinc oxide (14 mg) in a reactor vial under argon is added NMP (3 ml) and the reaction heated by microwaves irradiation at 160° C. After 120 min, water is added and the suspension extracted with DCM. Preparative HPLC provides 150 mg pure product (26%) as a beige solid. R.t. 4.81 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07759365B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-539983f68fff4a7cb10bbbe8046a7874 |
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| Source note | uspto-grants-2010_07 |
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