Thionyl Chloride → HCID 13784626, compound

HRID 235640Notes

Reaction equation

HRID 235640 reaction equation
O[CH2:2][CH2:3][CH:4]1[C:9](=[O:10])[NH:8][C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[S:5]1.S(Cl)([Cl:17])=O>>[Cl:17][CH2:2][CH2:3][CH:4]1[C:9](=[O:10])[NH:8][C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[S:5]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 146849742-(2-Hydroxyethyl)-2H-1,4-benzothiazin-3(4H)-one

Product 1

HCID 13784626HCID 13784626, compoundYield 72.7%

Procedure

By a process similar to that in Reference Example 13, 2-(2-hydroxyethyl)-2H-1,4-benzothiazin-3(4H)-one was allowed to react with thionyl chloride to give 2-(2-chloroethyl)-2H-1,4-benzothiazin-3(4H)-one. The yield was 72.7%. Recrystallization from methanol gave prisms, m.p. 133°-133.5° C.

Sources & evidence

ORD record
ord-0a716e6ee8e946b682011ee959090f6a
Source dataset
uspto-grants-1987_02
Patent number
US04640916

Reaction notes

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