6-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amide → HCID 86597212, compound

HRID 2356422Notes

Reaction equation

HRID 2356422 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([F:10])([F:9])[F:8])=[C:5]([C:11](Cl)=[O:12])[CH:4]=[N:3]1.[CH3:14][CH:15]([CH3:33])[CH2:16][CH2:17][NH:18][C:19]([C:21]1[N:22]=[N:23][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:25][CH:26]=1)=[O:20]>>[CH3:14][CH:15]([CH3:33])[CH2:16][CH2:17][NH:18][C:19]([C:21]1[N:22]=[N:23][C:24]([N:27]2[CH2:32][CH2:31][N:30]([C:11]([C:5]3[CH:4]=[N:3][N:2]([CH3:1])[C:6]=3[C:7]([F:10])([F:9])[F:8])=[O:12])[CH2:29][CH2:28]2)=[CH:25][CH:26]=1)=[O:20]

Participants

3

Reactant 2

HCID 668493226-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amideHCID 714640141-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride

Product 1

HCID 86597212HCID 86597212, compound

Procedure

Following the procedure of Example 3, making variations only as required to use 1-methyl-5-trifluoromethyl-1H-pyrazole-4-carbonyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (3-methylbutyl)amide, the title compound was obtained as a white powder (47% yield). 1H NMR (300 MHz, CDCl3) δ 8.04, 7.82, 7.54, 6.99, 3.97, 3.90-3.54, 3.51-3.44, 1.75-1.62, 1.53-1.46, 0.92. MS (ES+) m/z 454.3 (M+1).

Sources & evidence

ORD record
ord-45d652adfcbf47e28e1f27bfdebaabc9
Source dataset
uspto-grants-2010_07
Patent number
US07759348B2

Reaction notes

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