Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356435Generated: October 26, 2026

2,6-Difluorobenzoyl chloride → 6-[4-(2,6-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

https://huagongshe.com/reaction/2356435

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Difluorobenzoyl chlorideHCID 87438—
ReactantN-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamideHCID 66849327—
Product6-[4-(2,6-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDEHCID 11200833—

Reaction Steps

Following the procedure of Example 3, making variations only as required to use 2,6-difluorobenzoyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder (44% yield). 1H NMR (400 MHz, CDCl3) δ 8.07, 8.07-7.99, 7.44-7.38, 7.02-6.96, 4.0-3.99, 3.86-3.83, 3.58-3.50, 3.39-3.38, 1.52, 1.15-1.10, 0.77-0.74, 0.49-0.45, 0.11-0.08.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07759348B2
Source datasetuspto-grants-2010_07
ORD IDord-aadbe711f53e47de9d1a6ae9fa18702c
Source noteuspto-grants-2010_07