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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2356439생성일: 2026년 10월 25일

2,5-Difluorobenzoyl chloride → 6-[4-(2,5-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

https://huagongshe.com/reaction/2356439

반응식

참여 물질

역할이름HCID투입량
반응물2,5-Difluorobenzoyl chlorideHCID 588082—
반응물N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamideHCID 66849327—
생성물6-[4-(2,5-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDEHCID 11223757—

반응 단계

Following the procedure of Example 3, making variations only as required to use 2,5-difluorobenzoyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)-amide, the title compound was obtained as a white powder (53% yield). 1H NMR (400 MHz, CDCl3) δ 8.08, 8.0, 7.17-7.11, 7.03, 4.02-3.92, 3.85-3.83, 3.59-3.5, 1.52, 0.74-0.69, 0.46-0.40, 0.09-0.04.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07759348B2
출처 데이터셋uspto-grants-2010_07
ORD IDord-7310ef2878914883bb1be3d68d5d4598
출처 메모uspto-grants-2010_07