Ethyl chloroformate → HCID 66849694, compound

HRID 2356476Notes

Reaction equation

HRID 2356476 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[NH2:7][C:8]1[N:13]=[N:12][C:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]([F:31])([F:30])[F:29])=[O:21])[CH2:16][CH2:15]2)=[CH:10][CH:9]=1>>[CH2:5]([O:4][C:2](=[O:3])[NH:7][C:8]1[N:13]=[N:12][C:11]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]([F:31])([F:30])[F:29])[CH2:18][CH2:19]2)=[CH:10][CH:9]=1)[CH3:6]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 66849536[4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone

Product 1

HCID 66849694HCID 66849694, compound

Procedure

Following the procedure of Example 7, making variations only as required to use ethyl chloroformate in place of n-butyl chloroformate to react with [4-(6-aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone, the title compound was obtained as a light yellow solid (35% yield). 1H NMR (300 MHz, DMSO-d6) δ 10.30, 7.82-7.85, 7.76, 7.67, 7.52, 7.37, 4.15, 3.15-3.85, 1.10. MS (ES+) m/z 424 (M+1).

Sources & evidence

ORD record
ord-e233c5f144f64603808a1af45f4c81c4
Source dataset
uspto-grants-2010_07
Patent number
US07759348B2

Reaction notes

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