HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfanilic acid → 4-(7-Chloro-4-quinazolinylamino)benzenesulphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfanilic acid | HCID 8479 | — |
| Reactant | 4,7-Dichloroquinazoline | HCID 241881 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(7-Chloro-4-quinazolinylamino)benzenesulphonic acid | HCID 5070070 | — |
Reaction Steps
Sulphanilic acid (12.1 g, 0.07 mole) was partly dissolved in 280 milliliters of aqueous ethanol (50% by volume) at reflux and 4,7-dichloroquinazoline (13.9 g, 0.07 mole) was added rapidly in a few portions. The mixture was refluxed for a further 15 minutes, cooled and filtered to give the title compound hemihydrate of melting point greater than 300° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04640920 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-c67b16b9bcf045c5b305db6f3281943d |
| Source note | uspto-grants-1987_02 |