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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356491Generated: October 27, 2026

2-(Dimethylamino)benzoic acid → 6-[4-(2-DIMETHYLAMINOBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

https://huagongshe.com/reaction/2356491

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Dimethylamino)benzoic acidHCID 69118—
ReactantN-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamideHCID 66849327—
Product6-[4-(2-DIMETHYLAMINOBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDEHCID 11339214—

Reaction Steps

Following the procedure of Example 9, making variations only as required to use 2-dimethylaminobenzoic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white solid (61% yield). 1H NMR (300 MHz, CDCl3) δ 8.04, 7.96, 7.36-7.25, 7.05-6.94, 4.17-3.40, 2.80, 1.51, 0.80-0.73, 0.47-0.42, 0.12-0.07.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07759348B2
Source datasetuspto-grants-2010_07
ORD IDord-5d34a0881cb2432d9fbcd470f1fd00e0
Source noteuspto-grants-2010_07