HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Chloromethyl)-4-fluoro-1-(trifluoromethyl)benzene → 6-[4-(5-FLUORO-2-TRIFLUOROMETHYLBENZYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Chloromethyl)-4-fluoro-1-(trifluoromethyl)benzene | HCID 2759169 | — |
| Reactant | N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide | HCID 66849327 | — |
| Product | 6-[4-(5-FLUORO-2-TRIFLUOROMETHYLBENZYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE | HCID 11259492 | — |
Reaction Steps
Following the procedure of Example 11, making variations only as required to use 5-fluoro-2-trifluoromethylbenzyl chloride in place of 2-trifluoromethylbenzyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white solid (40% yield). 1H NMR (300 MHz, CDCl3) δ 7.95-8.01, 7.57-7.68, 7.04, 6.95, 3.79, 3.71, 3.56, 2.64, 1.51, 0.68-0.82, 0.43-0.51, 0.06-0.13. MS (ES+) m/z 452 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759348B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-e77a0a87c275440aa682e70af6ba7326 |
| Source note | uspto-grants-2010_07 |