反应详情

温度

3 °C

3-Amino-1-ethylpiperidine (0.4 ml) in chloroform (15 ml) was treated with anhydrous sodium carbonate (2.94 g) in water (15 ml) and cooled to 3° C. The mixture was vigorously stirred and treated with 4-(7-chloro-4-cinnolinylamino)benzenesulphonylchloride hydrochloride (1.0 g). The dark orange mixture was stirred at 3° C. for 15 minutes, then at room temperature for 45 minutes. During this period the colour lightened considerably. The chloroform layer was separated and dried over magnesium sulphate. The residue on evaporation solidified when triturated with methanol, to give the title compound (0.5 g), m.p. 213°-15° C. (with decomposition).

1. stirringThe dark orange mixture was stirred at 3° C. for 15 minutes
2. waitDuring this period the colour lightened considerably
3. customThe chloroform layer was separated
4. dry with materialdried over magnesium sulphate
5. customThe residue on evaporation
6. customtriturated with methanol