1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 16035877, compound

HRID 2356533Notes

Reaction equation

HRID 2356533 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=2)=[O:7])[CH2:3][CH2:2]1.[N:15]1([C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]([F:32])([F:31])[F:30])=[O:22])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[N:9]=[N:10][C:11]([N:18]3[CH2:19][CH2:20][N:15]([C:21](=[O:22])[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([F:32])([F:30])[F:31])[CH2:16][CH2:17]3)=[CH:12][CH:13]=2)=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 60859502HCID 60859502, compound

Product 1

HCID 16035877HCID 16035877, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid cyclopropylmethylamide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (31% yield). 1H NMR (500 MHz, CDCl3) δ 8.16-7.88, 7.75, 7.68-7.46, 7.18, 7.00, 4.17-3.64, 3.21-3.12, 1.07-1.00, 0.61-0.44, 0.26-0.20.

Sources & evidence

ORD record
ord-d9d04739112e4311b2657ffbd04edca1
Source dataset
uspto-grants-2010_07
Patent number
US07759348B2

Reaction notes

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