戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 2356540作成日：2026年10月25日

1-[2-(Trifluoromethyl)benzoyl]piperazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-PHENYLCYCLOPROPYLMETHYL)AMIDE

https://huagongshe.com/reaction/2356540

反応式

関与物質

役割名称HCID仕込み量
反応物1-[2-(Trifluoromethyl)benzoyl]piperazineHCID 16733784—
反応物6-Chloropyridazine-3-carboxylic acid (2-phenylcyclopropylmethyl)amideHCID 86025948—
生成物6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-PHENYLCYCLOPROPYLMETHYL)AMIDEHCID 11295159—

反応手順

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (2-phenylcyclopropylmethyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (25% yield). 1H NMR (400 MHz, CDCl3) δ 8.09-8.03, 7.76, 7.64, 7.57, 7.36, 7.28-7.21, 7.17-7.12, 7.07-6.96, 4.09-3.32, 1.92-1.86, 1.47-1.38, 1.01-0.96. MS (ES+) m/z 510.4 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07759348B2
出典データセットuspto-grants-2010_07
ORD IDord-6dde14f968694429ada5319759918c0c
出典メモuspto-grants-2010_07