tert-Butyl piperazine-1-carboxylate → HCID 11559881, compound

HRID 2356570Notes

Reaction equation

HRID 2356570 reaction equation
[CH3:1][CH:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1)=[O:7].[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([C:11]2[N:10]=[N:9][C:8]([C:6](=[O:7])[NH:5][CH2:4][CH2:3][CH:2]([CH3:15])[CH3:1])=[CH:13][CH:12]=2)[CH2:25][CH2:24]1)=[O:22])([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 167337866-chloro-N-(3-methylbutyl)pyridazine-3-carboxamide

Product 1

HCID 11559881HCID 11559881, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (3-methylbutyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazine-1-carboxylic acid t-butyl ester, the title compound was obtained as a white solid (83% yield). 1H NMR (500 MHz, CDCl3) δ8.03, 7.86, 6.97, 3.75, 3.56-3.63, 3.49, 1.65-1.76, 1.52, 0.94. MS (ES+) m/z 378 (M+1).

Sources & evidence

ORD record
ord-c295cfecb5ca410da476dbfa8e14d7cf
Source dataset
uspto-grants-2010_07
Patent number
US07759348B2

Reaction notes

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