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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356603Generated: October 26, 2026

Potassium Carbonate → HCID 59384259, compound

https://huagongshe.com/reaction/2356603

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactantalpha-Bromo-o-chlorotolueneHCID 11905—
ReactantEthyl 6-[(5-chloro-2-hydroxyphenyl)methyl]-2-pyridinecarboxylateHCID 59384254—
SolventDimethylformamideHCID 6228—
ProductHCID 59384259HCID 59384259—

Reaction Conditions

Temperature80 °C

Reaction Steps

A solution of ethyl 6-[(5-chloro-2-hydroxyphenyl)methyl]-2-pyridinecarboxylate (60 mg, 0.21 mmol) in dry dimethylformamide (2.1 ml) was stirred at room temperature under an atmosphere of argon. Potassium carbonate (44 mg, 0.32 mmol) was added to the stirred solution. 2-Chlorobenzyl bromide (51 mg, 0.25 mmol) was added to the stirred solution. The solution was heated to 80° C. for ˜17 hours (overnight). The reaction was worked up to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07759369B2
Source datasetuspto-grants-2010_07
ORD IDord-65fabd8a2c0441a9b9b2154916f17fa0
Source noteuspto-grants-2010_07