HCID 24753780, compound → HCID 11559437, compound

Participants

Reaction Steps

Ethyl 6-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-2-pyridinecarboxylate (5.26 g, 13.8 mmol) was stirred at 60° C. for 2 hours in ethanol (15 ml) and 2M sodium hydroxide solution (5 mL). The reaction mixture was cooled and evaporated. The residue was diluted with water and extracted with diethyl ether. The aqueous phase was then acidified with glacial acetic acid and extracted with ethyl acetate (2×30 mL), dried (MgSO4) and evaporated to give the title compound as a yellow oil (4.78 g).

Provenance & Evidence