HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Gsk-269984A
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 6-(5-chloro-2-((4-chloro-2-fluorobenzyl)oxy)benzyl)picolinate | HCID 59384237 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Gsk-269984A | HCID 23696973 | — |
Reaction Steps
Ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (421.4 mg, 0.97 mmol) was suspended in ethanol (4 ml) and 2M sodium hydroxide (1 ml) and heated at 90° C. for 1.75 hours. Reaction complete after about 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759369B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-70537d48873e4cba901481c0d29c3061 |
| Source note | uspto-grants-2010_07 |