HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl borate → (5-Chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)boronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl borate | HCID 8470 | — |
| Reactant | 4-Chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene | HCID 24753687 | — |
| Reactant | HCID 178418918 | HCID 178418918 | — |
| Product | (5-Chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)boronic acid | HCID 59384250 | — |
Reaction Steps
As for reaction 1, using 90.5 g 4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene, 228 ml isopropylmagnesium chloride and 47.42 g trimethyl borate. Yield 66.8 g. NMR showed trace impurities. LCMS OK.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759369B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-e3563bca37ad47acbaf70ac970b4d027 |
| Source note | uspto-grants-2010_07 |