HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-[4-(5-Bromo-3-methylpyrid-2-yl)-butylamino]-4-amino-1,2,5-thiadiazole-1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,4-Dimethoxy-1,2,5-thiadiazole 1-oxide | HCID 12913947 | — |
| Reactant | 4-(5-Bromo-3-methyl-2-pyridinyl)butylamine | HCID 13094272 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[4-(5-Bromo-3-methylpyrid-2-yl)-butylamino]-4-amino-1,2,5-thiadiazole-1-oxide | HCID 15962357 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (1.62 g) in methanol was reacted with a solution of 4-(5-bromo-3-methylpyrid-2-yl)-butylamine (2.43 g) in methanol. After 2 hours at room temperature, the reaction was cooled to 0° C. and saturated by passing ammonia gas for 10 mins. After 1.5 hours the product (which precipitated) was filtered off and recrystallised from ethanol to yield 3-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-4-amino-1,2,5-thiadiazole-1-oxide (1.12 g) m.p. 188°-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04640926 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-a0351c07fee64102a7e9aeb8b8589379 |
| Source note | uspto-grants-1987_02 |