HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 6-(Chloromethyl)-5-methyl-2-pyridinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 68458843 | HCID 68458843 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(Chloromethyl)-5-methyl-2-pyridinecarbonitrile | HCID 55298147 | 99% |
Reaction Steps
A solution of 6-(hydroxymethyl)-5-methyl-2-pyridinecarbonitrile (184 mg) and thionyl chloride (0.16 ml) in dichloromethane (3.5 ml) was stirred at ambient temperature for 7 hours. Solvent was removed in vacuo and toluene (2 ml) added then removed in vacuo to afford the title compound (205 mg, 99%) as a pale buff solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759369B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-ab1a1929872747a595afb436cc78c92e |
| Source note | uspto-grants-2010_07 |