HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-Methylamino-2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-cyclobut-1-ene-3,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 3-Cyclobutene-1,2-dione, 3,4-dimethoxy- | HCID 123227 | — |
| Reactant | 4-(5-Bromo-3-methyl-2-pyridinyl)butylamine | HCID 13094272 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-Methylamino-2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-cyclobut-1-ene-3,4-dione | HCID 14537453 | — |
Reaction Steps
Treatment of 1,2-dimethoxycyclobut-1-ene-3,4-dione with 4-(5-bromo-3-methylpyrid-2-yl)-butylamine in dry ether at 0° C. followed by methylamine in ethanol and chromatography in chloroform on silica gel yielded 1-methylamino-2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-cyclobut-1-ene-3,4-dione m.p. 190°-191° C. after recrystallisation from acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04640926 |
| Source dataset | uspto-grants-1987_02 |
| ORD ID | ord-2ed6ac3865a1489eb5ee6e582db217fa |
| Source note | uspto-grants-1987_02 |