HCID 68678132, compound → HCID 25211417, compound

HRID 2356643Notes

Reaction equation

HRID 2356643 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][C:10]=2[CH2:11][N:12]2[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=3)[C:13]2=[O:32])=[CH:4][CH:3]=1.COC1C=CC(NC2C=CC(C(F)(F)F)=CC=2)=C(C=1)CN1C(C)(C)C(=O)N(C2C=CC(C#N)=C(C(F)(F)F)C=2)C1=O>>[CH3:38][O:37][C:34]1[CH:35]=[CH:36][C:9]([NH:8][C:5]2[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=2)=[C:10]([CH:33]=1)[CH2:11][N:12]1[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:30])([F:31])[F:29])[CH:21]=2)[C:13]1=[O:32]

Participants

3

Reactant 2

HCID 68678132HCID 68678132, compoundHCID 86761146HCID 86761146, compound

Product 1

HCID 25211417HCID 25211417, compound

Procedure

The compounds of example 7, 4-{3-[2-(4-fluorophenylamino)-5-methoxybenzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 526.16 (C27H22F4N4O3); retention time Rt=2.19 min. [B]; MS (ESI): 527.13 (MH+), and of examples 8, 4-{3-[5-methoxy-2-(4-trifluoromethylphenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 576.15 (C28H22F6N4O3); retention time Rt=2.30 min. [B]; MS (ESI): 577.15 (MH+),

Sources & evidence

ORD record
ord-9960ca1cbb554c248e3e4260bf44d207
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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