HCID 68677564, compound → HCID 25211530, compound

HRID 2356645Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][C:10]=2[CH2:11][N:12]2[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=3)[C:13]2=[O:32])=[CH:4][CH:3]=1.[F:38]C1C=CC(NC2C=CC=CC=2)=C(C=1)CN1C(C)(C)C(=O)N(C2C=CC(C#N)=C(C(F)(F)F)C=2)C1=O>>[F:37][C:34]1[CH:35]=[CH:36][C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([F:38])=[CH:3][CH:4]=2)=[C:10]([CH:33]=1)[CH2:11][N:12]1[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=2)[C:13]1=[O:32]

Participants

Reactant 2

HCID 68677564HCID 68677564, compound

HCID 68678167HCID 68678167, compound

Product 1

HCID 25211530HCID 25211530, compound

Procedure

The compounds of example 16, 4-{3-[2-(4-chlorophenylamino)-5-fluorobenzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 530.11 (C26H19ClF4N4O2); retention time Rt=2.38 min. [B]; MS (ESI): 531.21 (MH+), and of example 18, 4-[3-(5-fluoro-2-phenylaminobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile (molecular weight 496.15 (C26H20F4N4O2); retention time Rt=2.28 min. [B]; MS (ESI): 497.20 (MH+)

Sources & evidence

ORD record: ord-55bdc62204e2431e90cdd7f187fc342d
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07759366B2

Reaction notes

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