4-Fluoroaniline → HCID 25211531, compound

HRID 2356647Notes

Reaction equation

HRID 2356647 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][C:10]=2[CH2:11][N:12]2[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=3)[C:13]2=[O:32])=[CH:4][CH:3]=1.[F:41]C1C=CC(N)=CC=1>>[F:41][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][C:10]=2[CH2:11][N:12]2[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=3)[C:13]2=[O:32])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 87538390HCID 87538390, compound

Product 1

HCID 25211531HCID 25211531, compound

Procedure

The compound of example 19, 4-{3-[2-(4-chlorophenylamino)-5-trifluoromethylbenzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 580.11 (C27H19ClF6N4O2); retention time Rt=3.21 min. [C]; MS (ESI): 581.18 (MH+) was prepared like the compound of example 17 with the difference that, in the second stage of the synthesis, instead of 4-fluoroaniline,

Workup

  1. customin the second stage of the synthesis

Sources & evidence

ORD record
ord-75cad4be7e9e45a7867145b7c5ce007f
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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