Aniline → HCID 25211634, compound

HRID 2356651Notes

Reaction equation

Br[C:2]1[CH:28]=[CH:27][CH:26]=[CH:25][C:3]=1[CH2:4][N:5]1[C:9]([CH3:11])([CH3:10])[C:8](=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:14]=2)[C:6]1=[O:24].[NH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:7]2[C:8](=[O:12])[C:9]([CH3:11])([CH3:10])[N:5]([CH2:4][C:3]3[CH:25]=[CH:26][CH:27]=[CH:28][C:2]=3[NH:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:6]2=[O:24])=[CH:14][C:15]=1[C:20]([F:23])([F:22])[F:21]

Participants

Reactant 2

HCID 6115Aniline

HCID 58154355HCID 58154355, compound2×

Product 1

HCID 25211634HCID 25211634, compoundYield 81%

Procedure

To prepare the compound of example 23, the procedure may be according to process “A”. Analogously to the method for example 1, stage 3, compound 23.2 was reacted with aniline. Compounds 23 was obtained in a yield of 81%. Molecular weight 471.14 (C25H21F4N3O2); retention time Rt=2.34 min. [B]; MS (ESI): 472.11 (MH+).

Sources & evidence

ORD record: ord-604fd6d7f5fb45a4b8189f9330a375fc
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07759366B2

Reaction notes

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