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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356655Generated: November 1, 2026

1-Bromo-2-(bromomethyl)-3,5-dichlorobenzene → 4-[3-(2-Bromo-4,6-dichlorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

https://huagongshe.com/reaction/2356655

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-(bromomethyl)-3,5-dichlorobenzeneHCID 10426068—
Reactant4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrileHCID 11162285—
Product4-[3-(2-Bromo-4,6-dichlorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrileHCID 8663359483%

Reaction Steps

Compound 35.2 was prepared as described for example 6.2, by reacting compound 1.1 with 2-bromo-4,6-dichlorobenzyl bromide 35.3. 4-[3-(2-Bromo-4,6-dichlorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile was obtained in a yield of 83%. 1H NMR: 8.35, d, 1H, 8.2, s, 1H, 8.05, d, 1H, 7.9, s, 1H, 7.8, s, 1H; 4.9, s, 2H, 1.35, s, 6H.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07759366B2
Source datasetuspto-grants-2010_07
ORD IDord-2a474bf9e3764cf7b3a51659dea2381e
Source noteuspto-grants-2010_07