反应详情

温度

0 °C

1 g (2.863 mmol) of 2-(3-pentafluorosulfanylphenyl)isoindole-1,3-dione 51.4 was dissolved at 0° C. in 3.29 ml of concentrated nitric acid, and the mixture was stirred at 0° C. for 2 h. Thereafter, the mixture was left to stand overnight at room temperature. The reaction solution was added to 50 g of ice-water and the mixture was stirred for 1 h; thereafter, the precipitate was filtered off with suction, washed with water, dried and purified by chromatography on silica gel with toluene as the eluent. 2-(4-Nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dione 51.5 with the melting point of 200-203° C. and 2-(2-nitro-5-pentafluorosulfanylphenyl)isoindole-1,3-dione 51.6 with the melting point of 175-177° C. were obtained in a ratio of 1:2.

1. waitThereafter, the mixture was left
2. waitto stand overnight at room temperature
3. stirringthe mixture was stirred for 1 h
4. filtrationthereafter, the precipitate was filtered off with suction
5. washwashed with water
6. customdried
7. custompurified by chromatography on silica gel with toluene as the eluent