2-Bromo-1-(bromomethyl)-4-fluorobenzene → HCID 59384229, compound

HRID 2356679Notes

Reaction equation

HRID 2356679 reaction equation
[CH:1]1([C:4]2[CH:11]=[C:10]([N:12]3[C:16](=[O:17])[C:15]([CH3:19])([CH3:18])[NH:14][C:13]3=[O:20])[CH:9]=[CH:8][C:5]=2[C:6]#[N:7])[CH2:3][CH2:2]1.[Br:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[CH2:29]Br>>[Br:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[CH2:29][N:14]1[C:15]([CH3:18])([CH3:19])[C:16](=[O:17])[N:12]([C:10]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH:1]3[CH2:2][CH2:3]3)[CH:11]=2)[C:13]1=[O:20]

Participants

3

Reactant 2

HCID 107069772-Bromo-1-(bromomethyl)-4-fluorobenzeneHCID 59384228Benzonitrile, 2-cyclopropyl-4-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-

Product 1

HCID 59384229HCID 59384229, compound

Procedure

Under conditions as described for the preparation of 1.2, compound 158.1 was reacted with 2-bromo-1-bromomethyl-4-fluorobenzene and afforded 158.2. Molecular weight 455.06 (C22H19BrFN3O2); retention time Rt=2.15 min. [B]; MS (ESI): 456.02 (MH+).

Sources & evidence

ORD record
ord-76210ebf73db43a9a3c976f090127942
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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