Thionyl Chloride → HCID 57318383, compound

HRID 2356683Notes

Reaction equation

HRID 2356683 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6].[Br:16][C:17]1[CH:22]=[CH:21]C(C2C=CC(C(O)=O)=CC=2)=[CH:19][CH:18]=1.S(Cl)(Cl)=O.CC(C)([O-])C.[Li+]>>[Br:16][C:17]1[CH:22]=[CH:21][C:15]([C:14]2[CH:13]=[CH:12][C:4]([C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])=[CH:3][CH:2]=2)=[CH:19][CH:18]=1

Participants

5

Reactant 4

HCID 24386Thionyl ChlorideHCID 28183884'-Bromo[1,1'-biphenyl]-4-carboxylic acidHCID 12051722t-butyl 3-bromo-4-methylbenzoateHCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)

Product 1

HCID 57318383HCID 57318383, compound

Procedure

Compound 210.1 was prepared as described for the preparation of 183.1 from 4′-bromobiphenyl-4-carboxylic acid, thionyl chloride and lithium tert-butoxide.

Sources & evidence

ORD record
ord-dc70357a00ec4033803503feaf370b61
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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