Benzophenone imine → HCID 57829303, compound

HRID 2356694Notes

Reaction equation

HRID 2356694 reaction equation
Br[C:2]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:3]=1[CH2:4][N:5]1[C:9]([CH3:11])([CH3:10])[C:8](=[O:12])[N:7]([C:13]2[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:16]([C:26]#[N:27])=[CH:15][CH:14]=2)[C:6]1=[O:28].[NH2:34]C1C=CC=CC=1CN1C(C)(C)C(=O)N(C2C=CC(C#N)=C(C(F)(F)F)C=2)C1=O.C(=N)(C1C=CC=CC=1)C1C=CC=CC=1>>[NH2:34][C:2]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:3]=1[CH2:4][N:5]1[C:9]([CH3:11])([CH3:10])[C:8](=[O:12])[N:7]([C:13]2[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:16]([C:26]#[N:27])=[CH:15][CH:14]=2)[C:6]1=[O:28]

Participants

4

Reactant 3

HCID 136809Benzophenone imineHCID 58154368HCID 58154368, compoundHCID 68676578HCID 68676578, compound

Product 1

HCID 57829303HCID 57829303, compound

Procedure

Compound 253.2 (5-[3-(2-bromo-4-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-4′-fluorobiphenyl-2-carbonitrile) was, as described for the preparation of 61.2, reacted with benzophenone imine to obtain 264.1. Molecular weight 446.15 (C25H20F2N4O2); retention time Rt=2.78 min. [E]; MS (ESI): 447.12 (MH+).

Sources & evidence

ORD record
ord-5a0fe51f1d264ee0823061ecb00b3775
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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