反应详情

In acetonitrile (80 ml) were dissolved 2,2-dichlorobutanal (16.2 g) and 4-fluorobenzaldehyde (14.9 g). To the solution was added dropwise 28% aqueous ammonia (135 ml) under ice-cooling, and the resulting mixture was stirred at room temperature for 4 days. Water was added to the reaction mixture and the mixture was extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure. The resulting residue was crystallized from methanol-diethyl ether to obtain 4-ethyl-2-(4-fluorophenyl)imidazole (9.36 g).

1. temperaturecooling
2. extractionthe mixture was extracted with chloroform
3. washThe organic layer was washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. customthe solvent was removed under reduced pressure
6. customThe resulting residue was crystallized from methanol-diethyl ether