1,4-Dioxane hydrochloride → HCID 67546554, compound

HRID 2356735Notes

Reaction equation

HRID 2356735 reaction equation
C(OC([NH:8][CH2:9][C:10]1[N:11]=[C:12]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[O:13][C:14]=1[C:15]1[CH:19]=[CH:18][S:17][CH:16]=1)=O)(C)(C)C.[ClH:27].O1CCOCC1>>[ClH:27].[NH2:8][CH2:9][C:10]1[N:11]=[C:12]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[O:13][C:14]=1[C:15]1[CH:19]=[CH:18][S:17][CH:16]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67547967HCID 67547967, compound

Product 1

HCID 67546554HCID 67546554, compound

Procedure

A solution of 4-(t-butoxycarbonylamino)methyl-2-(4-florophenyl)-5-(3-thienyl)oxazole (455 mg) in 4N hydrogen chloride-dioxane solution was stirred at room temperature for 13 hours. The reaction mixture was concentrated under reduced pressure and the remaining volatiles were removed by evaporation with toluene, and the resulting residue was triturated with diethyl ether to obtain 4-aminomethyl-2-(4-fluorophenyl)-5-(3-thienyl)oxazole hydrochloride (288 mg) as colorless powder.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe remaining volatiles were removed by evaporation with toluene
  3. customthe resulting residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-2a4a9c9d6f674ec6877fc3c82dd186ce
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

Loading…