Ammonia → HCID 67546567, compound

HRID 2356741Notes

Reaction equation

HRID 2356741 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:11]([CH2:13][C:14](OCC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[NH3:25]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:11]([CH2:13][C:14]([NH2:25])=[O:15])[N:12]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67547842Ethyl [2-(4-chlorophenyl)-5-phenyl-1,3-thiazol-4-yl]acetate

Product 1

HCID 67546567HCID 67546567, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 2-(4-chlorophenyl)-5-phenylthiazol-4-ylacetate (4.5 g) was dissolved in methanol (50 ml), and ammonia was saturated in the solution at 0° C. and the resulting mixture was allowed to stand at room temperature for 3 days. After removing the solvent, methanol was added to the residue. The resulting precipitate was collected and dried to obtain 2-(4-chloro-phenyl)-5-phenylthiazol-4-yl acetamide (4.2 g).

Workup

  1. customwas saturated in the solution at 0° C.
  2. customAfter removing the solvent, methanol
  3. additionwas added to the residue
  4. customThe resulting precipitate was collected
  5. customdried

Sources & evidence

ORD record
ord-a6da3f5dac2e49b8942d26de0881ad81
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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