Acetyl chloride → Methyl 4-bromo-2-methylbenzoate

Participants

Reaction Steps

4-Bromo-2-methylbenzoic acid (2.00 g, 9.30 mmol) was added to a solution of acetyl chloride (1.70 mL, 23.9 mmol) in methanol (30 mL). The mixture was allowed to stir at rt for 3 days and was then concentrated in vacuo. This gave 1.96 g (92%) of the title compound as a light brown oil. 1H NMR (400 MHz, CD2Cl2) 2.61 (s, 3H), 3.90 (s, 3H), 7.38-7.42 (m, 2H), 7.78 (d, 1H).

Provenance & Evidence