4-Bromo-2-fluoroaniline → N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine

HRID 2356797Notes

Reaction equation

HRID 2356797 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][C:11]3[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:4][CH:3]=1.ClC1SC2C=C([F:29])C=CC=2N=1.FC1C=C(Br)C=CC=1N>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[S:10][C:11]3[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:6]([F:29])[CH:7]=1

Participants

4

Reactant 3

HCID 1230504-Bromo-2-fluoroanilineHCID 20498702-Chloro-6-fluorobenzothiazoleHCID 7147099N-(4-bromophenyl)-6-fluoro-1,3-benzothiazol-2-amine

Product 1

HCID 7147089N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine

Procedure

In a similar manner to the procedure described above for the preparation of N-(4-bromophenyl)-6-fluoro-1,3-benzothiazol-2-amine, 2-chloro-6-fluoro-benzothiazole and 2-fluoro-4-bromoaniline were reacted together to provide N-(4-bromo-2-fluoro-phenyl)-6-fluoro-1,3-benzothiazol-2-amine as a solid. 1H NMR (DMSO-d6) δ 10.50 (s, 1H), 8.60 (t, 1H), 7.80 (d, 1H), 7.60 (m, 2H), 7.40 (d, 1H), 7.20 (m, 1H)).

Workup

  1. customwere reacted together

Sources & evidence

ORD record
ord-38114a3fadba430fbc09140502b1d703
Source dataset
uspto-grants-2010_07
Patent number
US07759376B2

Reaction notes

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