Methanol → HCID 59385247, compound

Participants

Reaction Steps

Methyl 3′-fluoro-4′-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-methoxybiphenyl-4-carboxylate (0.43 g, 1.01 mmol) was suspended in THF (10 mL), MeOH (5 mL) and water (5 mL), and NaOH (0.40 g, 10 mmol) was added. The reaction mixture was stirred at rt for 18 h. The reaction mixture was concentrated under reduced pressure, acidified with 2N HCl, and the resulting solid was collected by filtration. This yielded 0.41 g (99%) of the title compound as a light brown solid. LC/MS m/z 413.3 (MH+), retention time 3.44 min. 1H NMR (400 MHz, DMSO-d6) δ 3.91 (s, 3H), 7.17 (t, 1H), 7.24-7.29 (m, 2H), 7.58-7.78 (m, 5H), 8.63 (t, 1H), 10.45 (br, 1H).

Provenance & Evidence