Methanol → HCID 59385203, compound

Participants

Reaction Conditions

Reaction Steps

Butyl 4′-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-methoxybiphenyl-4-carboxylate (0.30 g, 0.43 mmol) and methyl 4′-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-methoxybiphenyl-4-carboxylate (0.13 g, 0.25 mmol) were combined in THF (6 mL), MeOH (6 mL) and water (3 mL), and then NaOH (0.09 g, 2.1 mmol) was added. The reaction mixture was heated at 50° C. for 3 h. Upon cooling to rt, the reaction mixture was concentrated under reduced pressure, acidified, and the resulting solid was collected by filtration. This yielded 0.286 g (87%) of the title compound. LC/MS m/z 395.2 (MH+), retention time 3.30 min. 1H NMR (400 MHz, DMSO-d6) δ 3.90 (s, 3H), 7.12-7.33 (m, 3H), 7.61-7.90 (m, 7H), 10.62 (br, 1H).

Provenance & Evidence