1-Aminocyclohexanecarboxylic acid → Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

HRID 2356815Notes

Reaction equation

HRID 2356815 reaction equation
[NH2:1][C:2]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[C:11]([Cl:14])(=O)C>CO>[ClH:14].[CH3:11][O:9][C:8]([C:2]1([NH2:1])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1)=[O:10]

Participants

4

Reactant 2

HCID 13661-Aminocyclohexanecarboxylic acidHCID 6367Acetyl chloride

Product 1

HCID 22645079Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Aminocyclohexanecarboxylic acid (1.00 g, 6.98 mmol) was added to a solution of acetyl chloride (0.60 mL, 8.44 mmol) in methanol (10 mL). The reaction mixture was allowed to stir for 18 h and then concentrated under reduced pressure. 1H NMR (400 MHz, CD3OD) δ 1.42-1.82 (m, 8H), 2.08-2.20 (m, 2H), 3.82 (s, 3).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-298e7ebaae4b47e5b7d5bca72ebcca6a
Source dataset
uspto-grants-2010_07
Patent number
US07759376B2

Reaction notes

Loading…