Hydrochloric Acid → HCID 59385221, compound

Participants

Reaction Steps

Iron powder (0.35 g, 6.2 mmol) was added to a solution of methyl N-[(3-methoxy-4′-nitrobiphenyl-4-yl)carbonyl]-L-valinate (0.30 g, 0.62 mmol) in ethanol (10 mL). Concentrated HCl (0.31 mL, 0.62 mmol) was added, and the mixture was heated at reflux for 1 h. Upon cooling to rt, the mixture was filtered through a pad of Celite®, and the filtrate was concentrated in vacuo. The material was purified by column chromatography (33% EtOAc in hexanes), yielding 0.296 g (quantitative) of the title compound. LC/MS m/z 357.2 (MI), retention time 2.34 min.

Provenance & Evidence