HCID 68458276, compound → HCID 68457327, compound

Participants

Reaction Steps

A suspension of 0.36 g (0.7 mmol) of {1-[2-tert-butyl-5-(1-methyl-4-phenylpiperidin-4-yl)-2H-pyrazol-3-ylcarbamoyl]ethyl}carbamic acid benzyl ester and 0.36 g of 10% Pd/C in 5.0 mL of absolute EtOH was agitated under 30 psi H2 for 16 h. The reaction mixture was filtered through Celite and 0.36 g of fresh 10% Pd/C was added to the filtrate which was again agitated under 30 psi H2 for 16 h. This process was repeated once more and, after a final filtration, the filtrate was concentrated. Purification on silica gel using 4% Et3N-MeOH as eluant afforded 2-amino-N-[2-tert-butyl-5-(1-methyl-4-phenylpiperidin-4-yl)-2H-pyrazol-3-yl]propionamide.

Provenance & Evidence