HCID 68459274, compound → HCID 178465232, compound

Participants

Reaction Steps

A solution of 0.04 g (0.1 mmol) of N-[2-tert-butyl-5-(1-methyl-4-phenylpiperidin-4-yl)-2H-pyrazol-3-yl]-2-[2-(3,5-difluorophenyl)-2-hydroxyacetylamino]propionamide in 2.0 mL of neat trifluoroacetic acid was refluxed for 15 min. The reaction mixture was then cooled to rt, quenched with sat. aq. NaHCO3 and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated. Purification on silica gel afforded 2-[2-(3,5-difluorophenyl)-2-hydroxyacetylamino]-N-[5-(1-methyl-4 phenylpiperidin-4-yl)-2H-pyrazol-3-yl]propionamide.

Provenance & Evidence