Acetic Anhydride → HCID 10159178, compound

HRID 2356882Notes

Reaction equation

HRID 2356882 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[C:10](=[O:29])[N:11]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][OH:28])[CH:22]=2)[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH:14]=1)#[N:2].[C:30](OC(=O)C)(=[O:32])[CH3:31]>N1C=CC=CC=1>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[C:10](=[O:29])[N:11]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][O:28][C:30](=[O:32])[CH3:31])[CH:22]=2)[CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH:14]=1)#[N:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10271065HCID 10271065, compound

Product 1

HCID 10159178HCID 10159178, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 56 mg of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-(3-hydroxymethylphenyl)-1,2-dihydropyridin-2-one were added 1 ml of acetic anhydride and 1 ml of pyridine and the mixture was stirred at room temperature for one night. The reaction solution was concentrated in vacuo and purified by an NH silica gel chromatography (hexane-ethyl acetate system) to give 30 mg of the title compound.

Workup

  1. concentrationThe reaction solution was concentrated in vacuo
  2. custompurified by an NH silica gel chromatography (hexane-ethyl acetate system)

Sources & evidence

ORD record
ord-80fe290647a9490dbc9b060b14dded11
Source dataset
uspto-grants-2010_07
Patent number
US07759367B2

Reaction notes

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