HCID 22319133, compound → (6-Methoxypyridin-3-yl)(pyridin-2-yl)methanone

HRID 2356918Notes

Reaction equation

HRID 2356918 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[OH:10])=[CH:5][N:4]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[N:4][CH:5]=1)=[O:10]

Participants

4

Reactant 1

HCID 22319133HCID 22319133, compound

Product 1

HCID 22319071(6-Methoxypyridin-3-yl)(pyridin-2-yl)methanoneYield 97.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

To a solution of 0.83 g of α-(2-methoxypyridin-5-yl)-2-pyridinemethanol in 20 ml of an acetone was added 1.70 g of activated manganese dioxide, followed by vigorously stirring at room temperature for 30 minutes. The resulting precipitates were filtered off and washed with acetone. Then, the filtrate was concentrated, to give 0.80 g of the title compound as a white solid.

Workup

  1. customThe resulting precipitates
  2. filtrationwere filtered off
  3. washwashed with acetone
  4. concentrationThen, the filtrate was concentrated

Sources & evidence

ORD record
ord-be0467899c6b4d129e51944e7d8115b8
Source dataset
uspto-grants-2010_07
Patent number
US07759367B2

Reaction notes

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