Imidazole → HCID 23110281, compound

Participants

Reaction Steps

To a solution of 317 mg di-imidazol-1-yl-methanone and 20 mg imidazole in 4 ml tetrahydrofuran a solution of 500 mg 3-(2,2-diethoxy-ethoxy)-4-methoxy-phenylamine in 2 ml tetrahydrofuran was slowly added at 0° C. After stirring at 0° C. for 1 hour 505 mg 2-methyl-2-[(quinolin-4-ylmethyl)-amino]-propionic acid methyl ester were added and the reaction mixture was allowed to warm up to room temperature. After 2 hours stirring at room temperature the solution was heated for 2 hours at 70° C. After cooling to room temperature the solvent of the mixture was removed under reduced pressure and the residue was purified by preparative HPLC (C18 reverse phase column, elution with a water/acetonitrile gradient with 0.1% trifluoroacetic acid). Lyophilization of the solution yielded a white solid. Yield: 300 mg

Provenance & Evidence