Chloroacetyl chloride → HCID 11671104, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 50 mg 3-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-5,5-dimethyl-1-quinolin-4-ylmethyl-imidazolidine-2,4-dione in 1 ml 1,2-dichloroethane 0.04 ml ethyl-diisopropylamine and 13.67 mg chloroacetylchloride were added at 0° C. After stirring for 1 hour at 0° C. 10.5 mg morpholine were added and the reaction mixture was stirred for 1 hour at room temperature. Then 10.5 mg morpholine were added and the mixture was stirred for further 16 hours at room temperature. After removing of the solvent under reduced pressure the residue was purified by preparative HPLC (C18 reverse phase column, elution with a water/acetonitrile gradient with 0.1% trifluoroacetic acid). Lyophilization of the solution yielded a white solid.

Provenance & Evidence