3-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dione → 3-[1-(1-Cyclohexylazetidin-3-yl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl]-5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dione

HRID 2356960Notes

Reaction equation

HRID 2356960 reaction equation
[CH3:1][C:2]1([CH3:27])[C:10]2[C:5](=[CH:6][C:7]([N:11]3[C:15](=[O:16])[C:14]([CH3:18])([CH3:17])[N:13]([CH2:19][C:20]4[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=4)[C:12]3=[O:26])=[CH:8][CH:9]=2)[NH:4][CH2:3]1.C(O)(=O)C(O)=O.CS(O[CH:39]1[CH2:42][N:41]([CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)[CH2:40]1)(=O)=O>>[CH:43]1([N:41]2[CH2:42][CH:39]([N:4]3[C:5]4[C:10](=[CH:9][CH:8]=[C:7]([N:11]5[C:15](=[O:16])[C:14]([CH3:17])([CH3:18])[N:13]([CH2:19][C:20]6[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=6)[C:12]5=[O:26])[CH:6]=4)[C:2]([CH3:27])([CH3:1])[CH2:3]3)[CH2:40]2)[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1

Participants

3

Reactant 2

HCID 669156853-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dioneHCID 866172261-Cyclohexylazetidin-3-yl methanesulphonate oxalate

Product 1

HCID 669156983-[1-(1-Cyclohexylazetidin-3-yl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl]-5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dione

Procedure

prepared as described for example 96 by reaction of 3-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dione with 1-cyclohexylazetidin-3-yl methanesulphonate oxalate

Workup

  1. customprepared

Sources & evidence

ORD record
ord-afe9de99249442478eff9833322ee466
Source dataset
uspto-grants-2010_07
Patent number
US07759379B2

Reaction notes

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